Cover Feature: Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Microflow Reactor (Chem. Eur. J. 27/2021)

Rapid (0.5 to 10 s), mild, inexpensive, and less wasteful lactamization was achieved using highly electrophilic triphosgene in a micro‐flow reactor. This work reports two methods using NMM and NMI, respectively. The slight difference in basicity is critical in the lactamization depending on the type of lactam. A plausible reaction mechanism was discussed. Various lactams as well as a cyclic peptide containing acid‐ and/or heat‐labile functional groups were synthesized in good to high yields without tedious purifications. More information can be found in the Full Paper by S. Fuse et al. (DOI: 10.1002/chem.202100059).