Cover Feature: Anthracene‐Based Cyclophanes with Selective Fluorescent Responses for TTP and GTP: Insights into Recognition and Sensing Mechanisms (Chem. Eur. J. 14/2019)

Cyclophanes with two anthracene rings can bind nucleoside triphosphates in aqueous solution. We have found that the five natural nucleotides produce not only different fluorescence responses upon binding to receptors, but also show different binding modes. For instance, TTP is bound though phosphate, while UTP forms stacking interactions with the anthracene ring. In the cover picture, nucleotides we associate with rays: the tail is a phosphate residue and the flat head is a nucleobase. Similar to the binding modes of nucleotides, three kinds of rays are hosted in different ways by large sea shells (macrocycles). The cover was designed by Aleksandr S. Oshchepkov and authors. More information can be found in the Full Paper by E. A. Kataev, et al. on page 3541.