CpCo III -Catalyzed Bis-isoquinolone Synthesis by C-H Annulation of Arylamide with 1,3-Diyne

CpCo III -Catalyzed Bis-isoquinolone Synthesis by C-H Annulation of Arylamide with 1,3-Diyne

Cp*Co -catalyzed highly regioselective mono- and bis-annulation of arylamides with 1,3-diynes using N-OMe as an internal oxidant is demonstrated. This atom-economical transformation does not require any external oxidant and tolerates many functional groups. Various symmetrical and unsymmetrical hete...

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Veröffentlicht in:Chemistry : a European journal 2017-12, Vol.23 (69), p.17454-17457
Hauptverfasser: Sen, Malay, Mandal, Rajib, Das, Ashis, Kalsi, Deepti, Sundararaju, Basker
Format: Artikel
Sprache:eng
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Zusammenfassung:Cp*Co -catalyzed highly regioselective mono- and bis-annulation of arylamides with 1,3-diynes using N-OMe as an internal oxidant is demonstrated. This atom-economical transformation does not require any external oxidant and tolerates many functional groups. Various symmetrical and unsymmetrical heterocycles (homo and hetero) are accessed with predictable regio- and chemoselectivity.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201704155