Silica‐Encapsulated Gd 3+ ‐Aggregated Gold Nanoclusters for In Vitro and In Vivo Multimodal Cancer Imaging

Silica‐Encapsulated Gd 3+ ‐Aggregated Gold Nanoclusters for In Vitro and In Vivo Multimodal Cancer Imaging

Gd 3+ ‐aggregated gold nanoclusters (AuNCs) encapsulated by silica shell (Gd 3+ ‐A‐AuNCs@SiO 2 NPs) were strategically designed and prepared. The as‐prepared nanoparticles exhibit aggregation‐enhanced fluorescence (AEF), with an intensity that is up to 3.8 times that of discrete AuNCs. The clusters...

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Veröffentlicht in:Chemistry : a European journal 2014-07, Vol.20 (29), p.8876-8882
Hauptverfasser: Wu, Xiaotong, Li, Chunxia, Liao, Suchan, Li, Lu, Wang, Tingting, Su, Zhongmin, Wang, Chungang, Zhao, Jihong, Sui, Changping, Lin, Jun
Format: Artikel
Sprache:eng
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Zusammenfassung:Gd 3+ ‐aggregated gold nanoclusters (AuNCs) encapsulated by silica shell (Gd 3+ ‐A‐AuNCs@SiO 2 NPs) were strategically designed and prepared. The as‐prepared nanoparticles exhibit aggregation‐enhanced fluorescence (AEF), with an intensity that is up to 3.8 times that of discrete AuNCs. The clusters served as novel nanoprobes for in vitro and in vivo multimodal (fluorescence, magnetic resonance, and computed X‐ray tomography) cancer imaging
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201403202