Nickel‐Catalyzed Csp 2 Csp 3 Bond Formation by CarbonFluorine Activation

We report herein a general catalytic method for Csp 2 Csp 3 bond formation through CF activation. The process uses an inexpensive nickel complex with either diorganozinc or alkylzinc halide reagents, including those with β‐hydrogen atoms. A variety of fluorine substitution patterns and functional groups can be readily incorporated. Sequential reactions involving different precatalysts and coupling partners permit the synthesis of densely functionalized fluorinated building blocks.