Electrochemical Synthesis of 3‐Bromoimidazo[1,2‐a]pyridines Directly from 2‐Aminopyridines and alpha‐Bromoketones
A highly efficient co‐electrolysis of 3‐bromoimidazo[1,2‐a]pyridines has been developed in a simple undivided cell without any external oxidant. This protocol proceeds smoothly to provide the products with a broad substrate scope through a domino condensation/bromination sequence. Importantly, it ca...
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| Veröffentlicht in: | ChemElectroChem 2019-05, Vol.6 (10), p.2733-2736 |
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| container_title | ChemElectroChem |
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| creator | Jian, Wen‐Qian Wang, Hai‐Bin Du, Ke‐Si Zhong, Wei‐Qiang Huang, Jing‐Mei |
| description | A highly efficient co‐electrolysis of 3‐bromoimidazo[1,2‐a]pyridines has been developed in a simple undivided cell without any external oxidant. This protocol proceeds smoothly to provide the products with a broad substrate scope through a domino condensation/bromination sequence. Importantly, it can be easily scaled up.
To scale: An efficient approach for the synthesis of 3‐bromoimidazo[1,2‐a]pyridines from 2‐aminopyridines and α‐bromoketones is developed. This protocol provides products with a broad substrate scope under ambient conditions and in the absence of any chemical oxidant. Importantly, it can be easily scaled up. |
| doi_str_mv | 10.1002/celc.201900406 |
| format | Article |
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To scale: An efficient approach for the synthesis of 3‐bromoimidazo[1,2‐a]pyridines from 2‐aminopyridines and α‐bromoketones is developed. This protocol provides products with a broad substrate scope under ambient conditions and in the absence of any chemical oxidant. Importantly, it can be easily scaled up.</description><identifier>ISSN: 2196-0216</identifier><identifier>EISSN: 2196-0216</identifier><identifier>DOI: 10.1002/celc.201900406</identifier><language>eng</language><subject>2-aminopyridines ; 3-bromo-imidazo[1,2-a]pyridines ; electrochemistry ; one-pot reaction ; α-bromoketones</subject><ispartof>ChemElectroChem, 2019-05, Vol.6 (10), p.2733-2736</ispartof><rights>2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3266-ddecf4d8a787d881e7faf4b25568f284bf49e48a3ea2823382b94b029bfb698a3</citedby><cites>FETCH-LOGICAL-c3266-ddecf4d8a787d881e7faf4b25568f284bf49e48a3ea2823382b94b029bfb698a3</cites><orcidid>0000-0003-2861-3856</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcelc.201900406$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcelc.201900406$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Jian, Wen‐Qian</creatorcontrib><creatorcontrib>Wang, Hai‐Bin</creatorcontrib><creatorcontrib>Du, Ke‐Si</creatorcontrib><creatorcontrib>Zhong, Wei‐Qiang</creatorcontrib><creatorcontrib>Huang, Jing‐Mei</creatorcontrib><title>Electrochemical Synthesis of 3‐Bromoimidazo[1,2‐a]pyridines Directly from 2‐Aminopyridines and alpha‐Bromoketones</title><title>ChemElectroChem</title><description>A highly efficient co‐electrolysis of 3‐bromoimidazo[1,2‐a]pyridines has been developed in a simple undivided cell without any external oxidant. This protocol proceeds smoothly to provide the products with a broad substrate scope through a domino condensation/bromination sequence. Importantly, it can be easily scaled up.
To scale: An efficient approach for the synthesis of 3‐bromoimidazo[1,2‐a]pyridines from 2‐aminopyridines and α‐bromoketones is developed. This protocol provides products with a broad substrate scope under ambient conditions and in the absence of any chemical oxidant. Importantly, it can be easily scaled up.</description><subject>2-aminopyridines</subject><subject>3-bromo-imidazo[1,2-a]pyridines</subject><subject>electrochemistry</subject><subject>one-pot reaction</subject><subject>α-bromoketones</subject><issn>2196-0216</issn><issn>2196-0216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkLtOwzAUhi0EElXpyuwHIOXYcV17LKEUpEoMwIRQ5PiiGpK4siuhMPEIPCNPQqoCZWM6R_9t-BA6JTAmAPRc21qPKRAJwIAfoAElkmdACT_88x-jUUrPAEAITHLBB6ib11ZvYtAr23itanzXtZuVTT7h4HD--f5xEUMTfOONeguP5Iz2knpad9Eb39qEL33sB-oOuz6Ht-6s8W3YB1RrsKrXK_Wz9WI3oTdO0JFTdbKj7ztED1fz--I6W94uborZMtM55TwzxmrHjFBTMTVCEDt1yrGKTiZcOCpY5Zi0TKjcKipongtaSVYBlZWruOz1IRrvdnUMKUXrynX0jYpdSaDcsiu37Mpfdn1B7gqvvrbdP-mymC-LffcLVp15aA</recordid><startdate>20190515</startdate><enddate>20190515</enddate><creator>Jian, Wen‐Qian</creator><creator>Wang, Hai‐Bin</creator><creator>Du, Ke‐Si</creator><creator>Zhong, Wei‐Qiang</creator><creator>Huang, Jing‐Mei</creator><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0003-2861-3856</orcidid></search><sort><creationdate>20190515</creationdate><title>Electrochemical Synthesis of 3‐Bromoimidazo[1,2‐a]pyridines Directly from 2‐Aminopyridines and alpha‐Bromoketones</title><author>Jian, Wen‐Qian ; Wang, Hai‐Bin ; Du, Ke‐Si ; Zhong, Wei‐Qiang ; Huang, Jing‐Mei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3266-ddecf4d8a787d881e7faf4b25568f284bf49e48a3ea2823382b94b029bfb698a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>2-aminopyridines</topic><topic>3-bromo-imidazo[1,2-a]pyridines</topic><topic>electrochemistry</topic><topic>one-pot reaction</topic><topic>α-bromoketones</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jian, Wen‐Qian</creatorcontrib><creatorcontrib>Wang, Hai‐Bin</creatorcontrib><creatorcontrib>Du, Ke‐Si</creatorcontrib><creatorcontrib>Zhong, Wei‐Qiang</creatorcontrib><creatorcontrib>Huang, Jing‐Mei</creatorcontrib><collection>CrossRef</collection><jtitle>ChemElectroChem</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jian, Wen‐Qian</au><au>Wang, Hai‐Bin</au><au>Du, Ke‐Si</au><au>Zhong, Wei‐Qiang</au><au>Huang, Jing‐Mei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrochemical Synthesis of 3‐Bromoimidazo[1,2‐a]pyridines Directly from 2‐Aminopyridines and alpha‐Bromoketones</atitle><jtitle>ChemElectroChem</jtitle><date>2019-05-15</date><risdate>2019</risdate><volume>6</volume><issue>10</issue><spage>2733</spage><epage>2736</epage><pages>2733-2736</pages><issn>2196-0216</issn><eissn>2196-0216</eissn><abstract>A highly efficient co‐electrolysis of 3‐bromoimidazo[1,2‐a]pyridines has been developed in a simple undivided cell without any external oxidant. This protocol proceeds smoothly to provide the products with a broad substrate scope through a domino condensation/bromination sequence. Importantly, it can be easily scaled up.
To scale: An efficient approach for the synthesis of 3‐bromoimidazo[1,2‐a]pyridines from 2‐aminopyridines and α‐bromoketones is developed. This protocol provides products with a broad substrate scope under ambient conditions and in the absence of any chemical oxidant. Importantly, it can be easily scaled up.</abstract><doi>10.1002/celc.201900406</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-2861-3856</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | 2-aminopyridines 3-bromo-imidazo[1,2-a]pyridines electrochemistry one-pot reaction α-bromoketones |
| title | Electrochemical Synthesis of 3‐Bromoimidazo[1,2‐a]pyridines Directly from 2‐Aminopyridines and alpha‐Bromoketones |
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