Application of Laser-Backscattering Instruments for In Situ Monitoring of Crystallization Processes - A Review

Laser‐backscattering instruments, such as the focused beam reflectance measurement or threefold dynamical optical reflectance measurement, are promising tools to aid crystallization process development, allowing an in situ, real‐time, and nondestructive measurement of particle size distributions. Besides the instrument principles, in detail geometrical and optical models are discussed which deconvolute the recorded chord length distribution. Emphasis is thereby laid on the influence of the suspension density on instrument recordings. The application of laser‐backscattering devices for determination of kinetic constants is discussed and future directions and perspectives are given. The principles of laser‐backscattering instruments, geometrical and optical models to deconvolute the recorded chord length distribution as well as the influence of suspension density on the measurement are reviewed and discussed. The application of these instruments for determination of kinetic constants is considered and future directions and perspectives are evaluated.