Directed Evolution of the Enzyme Monoamine Oxidase (MAO-N): Highly Efficient Chemo-enzymatic Deracemisation of the Alkaloid (±)-Crispine A

Crispine, at the double! Modification of the active site of the enzyme monoamine oxidase (MAO‐N) allows the efficient deracemisation of the alkaloid crispine A. Microwave‐enhanced chemical synthesis results in the rapid production of the racemic compound. Combining both techniques greatly shortens the time required for the synthesis of (R)‐crispine A.