Front Cover: Late‐Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins (ChemBioChem 10/2021)

Front Cover: Late‐Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins (ChemBioChem 10/2021)

Linear and branched hydrocarbon chains may be appended or crosslinked at selected cysteine positions in unprotected peptides and proteins. The method involves nucleophilic substitution assisted by a simple zinc salt under mild conditions and can be applied at late stages of synthesis. More informati...

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Veröffentlicht in:Chembiochem : a European journal of chemical biology 2021-05, Vol.22 (10), p.1686-1686
Hauptverfasser: Araujo, Aline D., Nguyen, Huy T., Fairlie, David P.
Format: Artikel
Sprache:eng
Schlagworte:
conjugation
cysteine lipidation
peptides
stapling
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Beschreibung
Zusammenfassung:Linear and branched hydrocarbon chains may be appended or crosslinked at selected cysteine positions in unprotected peptides and proteins. The method involves nucleophilic substitution assisted by a simple zinc salt under mild conditions and can be applied at late stages of synthesis. More information can be found in the Full Paper by A. D. de Araujo, H. T. Nguyen, D. P. Fairlie.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.202100189