Amyloid Fibrillar Meshwork Formation of Iron-Induced Oligomeric Species of Aβ40 with Phthalocyanine Tetrasulfonate and Its Toxic Consequences

Amyloid Fibrillar Meshwork Formation of Iron-Induced Oligomeric Species of Aβ40 with Phthalocyanine Tetrasulfonate and Its Toxic Consequences

Brain detoxification: Phthalocyanine tetrasulfonate (PcTS) transforms iron‐induced oligomeric species of Aβ40 into amyloid fibrillar meshworks; this coincidentally eliminates redox‐active metal ions and oligomeric species, both of which are toxic candidates.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chembiochem : a European journal of chemical biology 2008-11, Vol.9 (16), p.2602-2605
Hauptverfasser: Park, Jae-Woo, Ahn, Jung Sun, Lee, Jung-Ho, Bhak, Ghibom, Jung, Seunho, Paik, Seung R
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
bioinorganic chemistry
phthalocyanines
protein structures
reactive oxygen species
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Brain detoxification: Phthalocyanine tetrasulfonate (PcTS) transforms iron‐induced oligomeric species of Aβ40 into amyloid fibrillar meshworks; this coincidentally eliminates redox‐active metal ions and oligomeric species, both of which are toxic candidates.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200800343