Natural Products‐Based Fungicides: Synthesis and Antifungal Activity against Plant Pathogens of 2 H ‐Chromene Derivatives
Aiming to search for novel potential antifungal agents, forty 2 H ‐chromene analogs were designed, synthesized and their antifungal activity against some typical plant pathogenic fungi were firstly evaluated. The in vitro antifungal bioassays showed that some of the target compounds exhibited compar...
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Veröffentlicht in: | Chemistry & biodiversity 2022-11, Vol.19 (11) |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | Aiming to search for novel potential antifungal agents, forty 2
H
‐chromene analogs were designed, synthesized and their antifungal activity against some typical plant pathogenic fungi were firstly evaluated. The
in vitro
antifungal bioassays showed that some of the target compounds exhibited comparable or better inhibition activities than the commercial agricultural fungicide hymexazol. Especially compound
1m
displayed more promising fungicidal effect against
Alternaria alternate
(EC
50
=9.9 μg/mL) and
Botrytis cinerea
(EC
50
=9.4 μg/mL), which was significantly superior to hymexazol. Moreover,
in vivo
protective effects results also indicated that compound
1m
had an excellent potential for further development as a new botanical pesticide. |
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ISSN: | 1612-1872 1612-1880 |
DOI: | 10.1002/cbdv.202200802 |