A Highly Enantioselective Access to Chiral 1‐( β ‐Arylalkyl)‐1 H ‐1,2,4‐triazole Derivatives as Potential Agricultural Bactericides

A series of chiral 1‐( β ‐arylalkyl)‐1 H ‐1,2,4‐triazole derivatives has been designed as potential antifungal agents. The target triazoles have been synthesized by using a chiral auxiliary as a controlling reagent. All of the compounds were obtained with high ee values, reaching up to 99%. Preliminary bioassay results have revealed that most of the synthesized compounds display significantly higher fungicidal activities against the species Fusarium oxysporium, Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Dothiorella gregaria , and Colletotrichum gossypii than the commercial agent triadimefon. Moreover, some of the enantiomers have been found to display significant differences in activity.