The use of gas chromatography mass spectrometry in the evaluation of the synthesis of 3-dimethylaminomethyl-2-(3′, 4′-dichlorophenyl)bicyclo[2.2.2.] octane. A novel drug with potential antidepressant activity

Gas chromatography mass spectrometry was used to characterize compounds observed throughout the synthesis of a cis‐fused 3′,4′‐dichlorophenyl bicyclo‐octane, a potential CNS acting drug substance. An ortho chloro‐effect identified the isomeric 2′,4′‐dichlorophenyl impurities.