A stable isotope assay for pseudoracemic warfarin from human plasma samples

A stable isotope assay for pseudoracemic warfarin from human plasma samples

A pseudoracemic technique utilizing a stable isotope in one enantiomer was employed for the simultaneous determination of (R) and (S)‐warfarin from plasma of human subjects. The assay includes high performance liquid chromatographic clean‐up prior to mass spectral analysis to eliminate ion interfere...

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Veröffentlicht in:Biological Mass Spectrometry 1980-01, Vol.7 (1), p.35-40
Hauptverfasser: Howald, William N., Bush, Ernie D., Trager, William F., O'Reilly, Robert A., Motley, Catherine H.
Format: Artikel
Sprache:eng
Schlagworte:
Carbon Isotopes
Chromatography, High Pressure Liquid
Deuterium
Half-Life
Humans
Mass Spectrometry
Stereoisomerism
Warfarin - blood
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Zusammenfassung:A pseudoracemic technique utilizing a stable isotope in one enantiomer was employed for the simultaneous determination of (R) and (S)‐warfarin from plasma of human subjects. The assay includes high performance liquid chromatographic clean‐up prior to mass spectral analysis to eliminate ion interferences from either co‐administered drugs or contamination of the source. The assay is reliable, accurate and precise to within 5% at the submicrogram level.
ISSN:1052-9306
0306-042X
1096-9888
DOI:10.1002/bms.1200070108