Urinary excretion of valproate metabolites in children and adolescents

The objective of this communication is to describe the changes in the metabolic profile of valproic acid (VPA) from early to late childhood and adolescence. A cross‐sectional study of 12 children and adolescents attending a neurological outpatients department, who were medicated with VPA, was carrie...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2000-11, Vol.21 (8), p.327-330
Hauptverfasser:	Reith, David M., Andrews, Jaymie, Parker-Scott, Suzie, Eadie, Mervyn J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Aging - metabolism Anticonvulsants - urine Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Biotransformation Child Child, Preschool Chromatography, Gas Cross-Sectional Studies Drug Combinations Drug Interactions Female Humans Hydrolysis Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Triazines - pharmacokinetics Valproic Acid - urine
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Zusammenfassung:	The objective of this communication is to describe the changes in the metabolic profile of valproic acid (VPA) from early to late childhood and adolescence. A cross‐sectional study of 12 children and adolescents attending a neurological outpatients department, who were medicated with VPA, was carried out. The proportions of daily dose excreted as VPA‐glucuronide, 3‐oxo‐VPA and 4‐OH‐VPA were calculated by relating 24‐h recovery of these metabolites from urine to daily VPA dose. VPA, 3‐oxo‐VPA and 2‐en‐valproic acid (2‐en‐VPA) were measured in trough serum samples. VPA and its metabolites were measured using a capillary gas chromatograpy method. The proportion of daily dose recovered as VPA‐glucuronide in children 10 years and younger was smaller than in older children (p
ISSN:	0142-2782 1099-081X
DOI:	10.1002/bdd.247