Efficient Synthesis and Iodine-Functionalization of Pyrazoles via KIO 3 /PhSeSePh System under Acidic Conditions

Efficient Synthesis and Iodine-Functionalization of Pyrazoles via KIO 3 /PhSeSePh System under Acidic Conditions

This manuscript reports a novel method for the direct iodination of the C-4 pyrazole ring generated in situ by the reaction of 1,1,3,3-tetramethoxypropane and various hydrazines. In this approach, potassium iodate (KIO ) is used as the iodinating agent and (PhSe) is used as catalysts under acidic co...

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Veröffentlicht in:Chemistry, an Asian journal an Asian journal, 2024-12, Vol.19 (23), p.e202400749
Hauptverfasser: Peglow, Thiago J, Thomaz, João Pedro S S C, Nobre, Patrick C, Scimmi, Cecilia, Santi, Claudio, Nascimento, Vanessa
Format: Artikel
Sprache:eng
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Zusammenfassung:This manuscript reports a novel method for the direct iodination of the C-4 pyrazole ring generated in situ by the reaction of 1,1,3,3-tetramethoxypropane and various hydrazines. In this approach, potassium iodate (KIO ) is used as the iodinating agent and (PhSe) is used as catalysts under acidic conditions. This protocol provides a convenient method for the efficient synthesis of 4-iodo-1-aryl-1H-pyrazoles, valuable intermediates for several different coupling reactions.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202400749