Allopurinol Sensitivity in a Patient With Chronic Tophaceous Gout: Success of Intravenous Desensitization After Failure of Oral Desensitization

Sensitivity to allopurinol, which occurs in 10–15% of patients, can seriously limit the drug's use in chronic tophaceous gout. Oral allopurinol desensitization has been advocated for sensitive patients in whom use of the drug is warranted. We report the successful use of intravenous allopurinol...

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Veröffentlicht in:	Arthritis and rheumatism 1991-10, Vol.34 (10), p.1329-1331
Hauptverfasser:	Walz‐Leblanc, Barbara A. E., John Reynolds, W., Macfadden, Douglas K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Allopurinol - administration & dosage Allopurinol - adverse effects Chronic Disease Desensitization, Immunologic - methods Drug Hypersensitivity - immunology Drug Hypersensitivity - therapy Gout - drug therapy Humans Injections, Intravenous Male Middle Aged
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Zusammenfassung:	Sensitivity to allopurinol, which occurs in 10–15% of patients, can seriously limit the drug's use in chronic tophaceous gout. Oral allopurinol desensitization has been advocated for sensitive patients in whom use of the drug is warranted. We report the successful use of intravenous allopurinol desensitization in a patient with chronic tophaceous gout in whom oral desensitization had previously failed.
ISSN:	0004-3591 1529-0131
DOI:	10.1002/art.1780341020