Monozygotic twins discordant for systemic lupus erythematosus

Monozygotic twins discordant for systemic lupus erythematosus

A pair of monozygotic twins discordant for systemic lupus erythematosus (SLE) were studied and no differences noted in their immune response to tetanus toxoid, keyhole lympet hemocyanin, DNCB, delayed sensitivity, or antibody titers to viruses. Both were noted to have biologically false positive ser...

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Veröffentlicht in:Arthritis and rheumatism 1975-05, Vol.18 (3), p.193-200
Hauptverfasser: Yocum, Michael W., Grossman, Jay, Waterhouse, Christine, Abraham, George N., May‐June, Allyn G., Condemi, John J.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antibodies, Viral - analysis
Antigen-Antibody Reactions
Antigens, Viral
Autoantibodies
Castration
Diseases in Twins
Female
gamma-Globulins - metabolism
Hemagglutination Tests
Hemocyanins - immunology
Humans
Hypersensitivity, Delayed
Immunoglobulin Fragments - metabolism
Immunoglobulin kappa-Chains - metabolism
Immunoglobulin lambda-Chains - metabolism
Lupus Erythematosus, Systemic - etiology
Lymphocytes - immunology
Pregnancy
Tetanus Toxoid
Twins, Monozygotic
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Zusammenfassung:A pair of monozygotic twins discordant for systemic lupus erythematosus (SLE) were studied and no differences noted in their immune response to tetanus toxoid, keyhole lympet hemocyanin, DNCB, delayed sensitivity, or antibody titers to viruses. Both were noted to have biologically false positive serology at an early age, but only one twin developed SLE. The clinically unaffected twin underwent castration at an early age, suggesting that ovarian hormones May‐June play an important role in the development of SLE.
ISSN:0004-3591
1529-0131
DOI:10.1002/art.1780180301