Novel lβ-Methylcarbapenems Having Cyclic Sulfonamide Moieties: Synthesis and Evaluation of in-vitro Biological Activity - Part II
The synthesis of a new series of 1β‐methylcarbapenems having cyclic sulfonamide moieties is described. Their in‐vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of a substituent on the pyrrolidine ring was investigated. One particular co...
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| Veröffentlicht in: | Archiv der Pharmazie (Weinheim) 2009-09, Vol.342 (9), p.528-532 |
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| container_end_page | 532 |
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| container_issue | 9 |
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| container_title | Archiv der Pharmazie (Weinheim) |
| container_volume | 342 |
| creator | Kim, Seong Jong Cho, Jung-Hyuck Oh, Chang-Hyun |
| description | The synthesis of a new series of 1β‐methylcarbapenems having cyclic sulfonamide moieties is described. Their in‐vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of a substituent on the pyrrolidine ring was investigated. One particular compound IIIe having a [1,2,5]thiadiazolidin 1,1‐dioxide moiety showed the most potent antibacterial activity. |
| doi_str_mv | 10.1002/ardp.200800226 |
| format | Article |
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| language | eng |
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| source | Access via Wiley Online Library |
| subjects | 1β-Methylcarbapenems Antibacterial activity Substituent effects |
| title | Novel lβ-Methylcarbapenems Having Cyclic Sulfonamide Moieties: Synthesis and Evaluation of in-vitro Biological Activity - Part II |
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