Novel lβ-Methylcarbapenems Having Cyclic Sulfonamide Moieties: Synthesis and Evaluation of in-vitro Biological Activity - Part II

Novel lβ-Methylcarbapenems Having Cyclic Sulfonamide Moieties: Synthesis and Evaluation of in-vitro Biological Activity - Part II

The synthesis of a new series of 1β‐methylcarbapenems having cyclic sulfonamide moieties is described. Their in‐vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of a substituent on the pyrrolidine ring was investigated. One particular co...

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Veröffentlicht in:Archiv der Pharmazie (Weinheim) 2009-09, Vol.342 (9), p.528-532
Hauptverfasser: Kim, Seong Jong, Cho, Jung-Hyuck, Oh, Chang-Hyun
Format: Artikel
Sprache:eng
Schlagworte:
1β-Methylcarbapenems
Antibacterial activity
Substituent effects
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Zusammenfassung:The synthesis of a new series of 1β‐methylcarbapenems having cyclic sulfonamide moieties is described. Their in‐vitro antibacterial activities against both Gram‐positive and Gram‐negative bacteria were tested and the effect of a substituent on the pyrrolidine ring was investigated. One particular compound IIIe having a [1,2,5]thiadiazolidin 1,1‐dioxide moiety showed the most potent antibacterial activity.
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.200800226