Synthesis and Antiprotozoal Evaluation of New N 4 ‐(Benzyl)spermidyl‐linked bis(1,3,5‐thiadiazinane‐2‐thiones)

Synthesis and Antiprotozoal Evaluation of New N 4 ‐(Benzyl)spermidyl‐linked bis(1,3,5‐thiadiazinane‐2‐thiones)

The synthesis and in‐vitro antiprotozoal evaluation of novel N 4 ‐(benzyl)spermidyl‐linked bis(1,3,5‐thiadiazinane‐2‐thione) (bis‐THTT) derivatives from N 4 ‐(benzyl)spermidine is disclosed. Several of the new bis‐THTT have in‐vitro activities against L. donovani and T. cruzi that are comparable or...

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Veröffentlicht in:Archiv der Pharmazie (Weinheim) 2008-11, Vol.341 (11), p.708-713
Hauptverfasser: Coro, Julieta, Little, Susan, Yardley, Vanessa, Suárez, Margarita, Rodríguez, Hortensia, Martín, Nazario, Perez‐Pineiro, Rolando
Format: Artikel
Sprache:eng
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Zusammenfassung:The synthesis and in‐vitro antiprotozoal evaluation of novel N 4 ‐(benzyl)spermidyl‐linked bis(1,3,5‐thiadiazinane‐2‐thione) (bis‐THTT) derivatives from N 4 ‐(benzyl)spermidine is disclosed. Several of the new bis‐THTT have in‐vitro activities against L. donovani and T. cruzi that are comparable or superior to those of currently employed protozoocidal agents.
ISSN:0365-6233
1521-4184
DOI:10.1002/ardp.200800011