Synthesis and Antimicrobial Properties of New 4‐(Alkylidene/arylidene)‐amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3 H ‐1,2,4‐triazole‐3‐thiones and 6‐Aryl‐3‐(2‐furanyl)‐7 H ‐1,2,4‐triazolo[3,4‐ b ][1,3,4]thiadiazines

A series of 4‐(alkylidene/arylidene)amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3 H ‐1,2,4‐triazole‐3‐thiones ( 2 ) and 6‐aryl‐3‐(2‐furanyl)‐7 H ‐1,2,4‐triazolo[3,4‐ b ][1,3,4] thiadiazines ( 3 ) were synthesized. The configuration of 2g was assigned on the basis of 1 H‐NMR data. Of the new derivatives tested, only 2b, 2g , and 4f were found to be active against Staphylococcus aureus and/or Staphylococcus epidermidis (MIC 125–1.95 μg/ml), whereas all exhibited varying degrees of antifungal activity (MIC 25–0.8 μg/ml).