Diffusion-controlled polymer dissolution and drug release

Diffusion-controlled polymer dissolution and drug release

A model is formulated for diffusion‐controlled polymer dissolution and simultaneous drug release for amorphous, uncrosslinked polymers. Calculated fractional drug release versus time curves are similar to experimental curves reported in the literature. Solutions of the transport equations provide a...

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Veröffentlicht in:Journal of applied polymer science 2004-07, Vol.93 (1), p.92-99
Hauptverfasser: Vrentas, J. S., Vrentas, C. M.
Format: Artikel
Sprache:eng
Schlagworte:
amorphous
Applied sciences
diffusion
drug delivery systems
Exact sciences and technology
modeling
Physicochemistry of polymers
Polymer industry, paints, wood
Technology of polymers
theory
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Zusammenfassung:A model is formulated for diffusion‐controlled polymer dissolution and simultaneous drug release for amorphous, uncrosslinked polymers. Calculated fractional drug release versus time curves are similar to experimental curves reported in the literature. Solutions of the transport equations provide a way of illustrating how polymer type and molecular weight can be used in an attempt to approach a constant drug release rate. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 93: 92–99, 2004
ISSN:0021-8995
1097-4628
DOI:10.1002/app.20406