Fe 3 O 4 /CuO/ZnO@MWCNT MNCs as an efficient organometallic nanocatalyst promoted synthesis of new 1,2,4‐triazolpyrimidoazepine derivatives: Investigation of antioxidant and antimicrobial activity

In this study, we synthesized new 1,2,4‐triazolpyrimidoazepine derivatives in high yields using multicomponent reactions of isatins, alkyl bromides, activated acetylenic compounds, guanidine, aldehydes, and hydrazonoyl chloride in the presence of Fe 3 O 4 /CuO/ZnO@MWCNT as a high performance catalyst in water at room temperature. The Fe 3 O 4 /CuO/ZnO@MWCNT synthesizes using Petasites hybridus rhizome water extract as a green media and moderate base. As well Fe 3 O 4 /CuO/ZnO@MWCNT MNCs show a good improvement in the yield of the product and displayed significant reusable activity. Investigation of antioxidant ability of synthesized compounds using radical trapping of diphenyl‐picrylhydrazine (DPPH) and ferric reduction power experiment is another purpose in this research. Also, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on Gram‐positive and Gram‐negative bacteria. This procedure has some benefits such as short reaction time, product with excellent yields, simple catalyst, and products separation.