Exceptionally high in vitro antitumor activity of substituted triphenyltin benzoates including salicylates against a human mammary tumor, MCF-7, and a colon carcinoma, WiDr

Nine new substituted triphenyltin benzoates of the type Ar3SnOOCC6H2XYZ [X = Y = H, Z = 2‐OCH3 and 4‐F; X = H, Y = 3‐F, Z = 5‐F; X = H, Y = 2‐OH, Z = 5‐Cl, 5‐NH2, 5‐OCH3 and 5‐SO3H; X = 2‐OH, Y = 3‐CH(CH3)2 and Z = 5‐CH(CH3)2] were prepared and possess considerable in vitro antitumor activity agai...

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Veröffentlicht in:	Applied organometallic chemistry 1992-05, Vol.6 (3), p.287-291
Hauptverfasser:	Gielen, M, Willem, R, Biesemans, M, Bouǎlam, M, Khloufi, A El, de Vos, D
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumor benzoates Chemistry Exact sciences and technology Ge, sn, pb derivatives Mössbauer NMR Organic chemistry Organometalloidal and organometallic compounds Preparations and properties Triphenyltin
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Zusammenfassung:	Nine new substituted triphenyltin benzoates of the type Ar3SnOOCC6H2XYZ [X = Y = H, Z = 2‐OCH3 and 4‐F; X = H, Y = 3‐F, Z = 5‐F; X = H, Y = 2‐OH, Z = 5‐Cl, 5‐NH2, 5‐OCH3 and 5‐SO3H; X = 2‐OH, Y = 3‐CH(CH3)2 and Z = 5‐CH(CH3)2] were prepared and possess considerable in vitro antitumor activity against two human tumor cell lines (MCF‐7, a mammary tumor, and WiDr, a colon carcinoma) comparable with that of mitomycin C.
ISSN:	0268-2605 1099-0739
DOI:	10.1002/aoc.590060307