Manganese(I)-Catalyzed Highly Enantioselective Synthesis of Aziridine Phosphines

Herein, we present the first catalytic asymmetric nucleophilic addition of diarylphosphines to 2H-azirines, facilitated by a chiral Mn(I) complex. This method not only provides access to novel class of derivatives of the aziridine core-a structural motif recognized for its antitumor and antibacteria...

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Veröffentlicht in:Angewandte Chemie International Edition 2024-11, p.e202415623
Hauptverfasser: Harutyunyan, Syuzanna R, Ni, Chuang, Ramspoth, Tizian-Frank, Reis, Marta Castiñeira
Format: Artikel
Sprache:eng
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Zusammenfassung:Herein, we present the first catalytic asymmetric nucleophilic addition of diarylphosphines to 2H-azirines, facilitated by a chiral Mn(I) complex. This method not only provides access to novel class of derivatives of the aziridine core-a structural motif recognized for its antitumor and antibacterial properties-but also introduces a phosphine moiety alongside the generation of an NH moiety within a strained three-membered ring. The discovery of this new Mn(I) complex that both enables the reaction and induces stereoselectivity is pivotal, as it underscores the significant potential of this earth-abundant metal in advancing asymmetric catalysis.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202415623