Cover Picture: Standardization and Control of Grignard Reactions in a Universal Chemical Synthesis Machine using online NMR (Angew. Chem. Int. Ed. 43/2021)

The digitization of chemistry requires that synthesis procedures can be written and optimized in a chemical programming language to perform reliable “chemputation” for the synthesis on the “chemputer” robot, a universal synthesis machine. The cover image shows how a universal chemical synthesis engine equipped with an NMR sensor can be used to optimize reactions producing the automated synthesis procedure as an optimized process code ensuring that the chemputation can be improved and is reliable. Details are reported by Leroy Cronin, Franziska Emmerling et al. in their Communication on page 23202.