Back Cover: Antiprotozoal Structure–Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action (Angew. Chem. Int. Ed. 28/2021)
Leucinostatins are fascinating natural substances, with high potency against many pathogens, but their acute toxicity has prevented therapeutic use. Michael Adams, Rainer Riedl, and co‐workers demonstrate in the Research Article on page 15613 how these can be converted into synthetically more access...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2021-07, Vol.60 (28), p.15660-15660 |
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| container_issue | 28 |
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| container_title | Angewandte Chemie International Edition |
| container_volume | 60 |
| creator | Brand, Michael Wang, Lei Agnello, Stefano Gazzola, Silvia Gall, Flavio M. Raguž, Luka Kaiser, Marcel Schmidt, Remo S. Ritschl, Amélie Jelk, Jennifer Hemphill, Andrew Mäser, Pascal Bütikofer, Peter Adams, Michael Riedl, Rainer |
| description | Leucinostatins are fascinating natural substances, with high potency against many pathogens, but their acute toxicity has prevented therapeutic use. Michael Adams, Rainer Riedl, and co‐workers demonstrate in the Research Article on page 15613 how these can be converted into synthetically more accessible and more selective antiprotozoal agents with broad efficacy and undetectable resistance. |
| doi_str_mv | 10.1002/anie.202104896 |
| format | Article |
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| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie International Edition, 2021-07, Vol.60 (28), p.15660-15660 |
| issn | 1433-7851 1521-3773 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_anie_202104896 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | antiparasitic agent drug discovery medicinal chemistry mode of action peptides |
| title | Back Cover: Antiprotozoal Structure–Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action (Angew. Chem. Int. Ed. 28/2021) |
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