Back Cover: Antiprotozoal Structure–Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action (Angew. Chem. Int. Ed. 28/2021)

Back Cover: Antiprotozoal Structure–Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action (Angew. Chem. Int. Ed. 28/2021)

Leucinostatins are fascinating natural substances, with high potency against many pathogens, but their acute toxicity has prevented therapeutic use. Michael Adams, Rainer Riedl, and co‐workers demonstrate in the Research Article on page 15613 how these can be converted into synthetically more access...

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Veröffentlicht in:Angewandte Chemie International Edition 2021-07, Vol.60 (28), p.15660-15660
Hauptverfasser: Brand, Michael, Wang, Lei, Agnello, Stefano, Gazzola, Silvia, Gall, Flavio M., Raguž, Luka, Kaiser, Marcel, Schmidt, Remo S., Ritschl, Amélie, Jelk, Jennifer, Hemphill, Andrew, Mäser, Pascal, Bütikofer, Peter, Adams, Michael, Riedl, Rainer
Format: Artikel
Sprache:eng
Schlagworte:
antiparasitic agent
drug discovery
medicinal chemistry
mode of action
peptides
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Zusammenfassung:Leucinostatins are fascinating natural substances, with high potency against many pathogens, but their acute toxicity has prevented therapeutic use. Michael Adams, Rainer Riedl, and co‐workers demonstrate in the Research Article on page 15613 how these can be converted into synthetically more accessible and more selective antiprotozoal agents with broad efficacy and undetectable resistance.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.202104896