Inside Cover: Mechanochemical Release of Non‐Covalently Bound Guests from a Polymer‐Decorated Supramolecular Cage (Angew. Chem. Int. Ed. 24/2021)

A supramolecular coordination cage in the center of a star‐shaped water‐soluble polymer responds to ultrasonication‐induced shear force in solution. As reported by Robert Göstl, Bernd M. Schmidt, and co‐workers in their Communication on page 13626, the octahedral Pd cage (blue panels) bearing polymer chains (red) on each vertex (metallic) encapsulates pharmaceutically active cargo within its hydrophobic nanocavity and is activated by sonication in aqueous solution, with complete cargo release upon rupture.