Inside Back Cover: Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification (Angew. Chem. Int. Ed. 27/2018)

Inside Back Cover: Rational Tuning of Fluorobenzene Probes for Cysteine‐Selective Protein Modification (Angew. Chem. Int. Ed. 27/2018)

Site‐selective cysteine arylation has been achieved by rational 2D reactivity tuning of fluorobenzene probes. In their Communication on page 8022 ff., M. Meldal, F. Diness et al. demonstrate how probes may be tailored to selectively target cysteine‐containing proteins by adjusting the numbers of flu...

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Veröffentlicht in:Angewandte Chemie International Edition 2018-07, Vol.57 (27), p.8831-8831
Hauptverfasser: Embaby, Ahmed M., Schoffelen, Sanne, Kofoed, Christian, Meldal, Morten, Diness, Frederik
Format: Artikel
Sprache:eng
Schlagworte:
arylation
enzymes
fluorination
inhibitors
protein modification
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Zusammenfassung:Site‐selective cysteine arylation has been achieved by rational 2D reactivity tuning of fluorobenzene probes. In their Communication on page 8022 ff., M. Meldal, F. Diness et al. demonstrate how probes may be tailored to selectively target cysteine‐containing proteins by adjusting the numbers of fluoro substituents (Fx) and by selecting substituents based on their electron‐withdrawing capacity represented by their Hammett σp constant.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201805102