Cover Picture: Mapping the Relationship between Glycosyl Acceptor Reactivity and Glycosylation Stereoselectivity (Angew. Chem. Int. Ed. 27/2018)

Cover Picture: Mapping the Relationship between Glycosyl Acceptor Reactivity and Glycosylation Stereoselectivity (Angew. Chem. Int. Ed. 27/2018)

The stereoselectivity of glycosylation … … reactions can depend critically on the reactivity of the acceptor glycoside (the nucleophile in the reaction). In their Communication on page 8240 ff., J. D. Codée et al. report a facile system that maps the relationship between glycosyl acceptor reactivity...

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Veröffentlicht in:Angewandte Chemie International Edition 2018-07, Vol.57 (27), p.7905-7905
Hauptverfasser: van der Vorm, Stefan, van Hengst, Jacob M. A., Bakker, Marloes, Overkleeft, Herman S., van der Marel, Gijsbert A., Codée, Jeroen D. C.
Format: Artikel
Sprache:eng
Schlagworte:
acceptor reactivity
enzyme mechanisms
glycosylation
reactivity tuning
stereoselectivity
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Zusammenfassung:The stereoselectivity of glycosylation … … reactions can depend critically on the reactivity of the acceptor glycoside (the nucleophile in the reaction). In their Communication on page 8240 ff., J. D. Codée et al. report a facile system that maps the relationship between glycosyl acceptor reactivity and glycosylation stereoselectivity. Tuning the reactivity of the nucleophile through the judicious choice of protecting groups can provide stereoselective 1,2‐cis‐glycosylations.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201804576