Direct Synthesis of Pyrroles by Dehydrogenative Coupling of β-Aminoalcohols with Secondary Alcohols Catalyzed by Ruthenium Pincer Complexes

Direct Synthesis of Pyrroles by Dehydrogenative Coupling of β-Aminoalcohols with Secondary Alcohols Catalyzed by Ruthenium Pincer Complexes

Pyrroles were synthesized in one step by using the acceptorless dehydrogenative coupling of amino alcohols with secondary alcohols (equivalent amounts), catalyzed by ruthenium pincer complexes (0.5 mol %) and a base (less than stoichiometric amounts) through selective CN and CC bond formation. Thi...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-04, Vol.52 (14), p.4012-4015
Hauptverfasser: Srimani, Dipankar, Ben-David, Yehoshoa, Milstein, David
Format: Artikel
Sprache:eng
Schlagworte:
Amino Alcohols - chemistry
Carbon - chemistry
Catalysis
Coordination Complexes - chemistry
dehydrogenation
homogeneous catalysis
Nitrogen - chemistry
pincer complex
pyrroles
Pyrroles - chemical synthesis
Pyrroles - chemistry
ruthenium
Ruthenium - chemistry
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Beschreibung
Zusammenfassung:Pyrroles were synthesized in one step by using the acceptorless dehydrogenative coupling of amino alcohols with secondary alcohols (equivalent amounts), catalyzed by ruthenium pincer complexes (0.5 mol %) and a base (less than stoichiometric amounts) through selective CN and CC bond formation. This atom‐economical, environmentally friendly methodology offers easy access to a range of substituted pyrroles in moderate to good yields.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201300574