A High-Performance Ytterbium-Based Nanoparticulate Contrast Agent for In Vivo X-Ray Computed Tomography Imaging

Enlightening particles: A contrast agent for in vivo X‐ray computed tomography (CT) imaging is composed of an Yb‐based nanoparticle (NP) that is stabilized with oleic acid and modified with the biocompatible polymer DSPE‐PEG 2000 (see picture). The contrast agent exhibits long circulation time in vi...

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Veröffentlicht in:	Angewandte Chemie International Edition 2012-02, Vol.51 (6), p.1437-1442
Hauptverfasser:	Liu, Yanlan, Ai, Kelong, Liu, Jianhua, Yuan, Qinghai, He, Yangyang, Lu, Lehui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Contrast Media - chemistry HeLa Cells Humans imaging agents magnetic resonance imaging Metal Nanoparticles - chemistry nanoparticles Rats Tomography, X-Ray Computed - methods X-ray computed tomography ytterbium Ytterbium - chemistry
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Beschreibung
Zusammenfassung:	Enlightening particles: A contrast agent for in vivo X‐ray computed tomography (CT) imaging is composed of an Yb‐based nanoparticle (NP) that is stabilized with oleic acid and modified with the biocompatible polymer DSPE‐PEG 2000 (see picture). The contrast agent exhibits long circulation time in vivo and low toxicity and is also much more effective than a clinical iodinated agent.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201106686