Palladium-Catalyzed Amidation of Unactivated C(sp³)----H Bonds: from Anilines to Indolines

Palladium-Catalyzed Amidation of Unactivated C(sp³)----H Bonds: from Anilines to Indolines

Unreactive CH to attractive CN: A palladium‐catalyzed intramolecular direct amidation of unactivated C(sp3)H bonds combines CH activation and CN bond formation into one efficient process. Under the optimized conditions, an extraordinary tolerance of functional groups was observed, and numerous...

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Veröffentlicht in:Angewandte Chemie (International ed.) 2009-01, Vol.48 (37), p.6892-6895
Hauptverfasser: Neumann, Julia J, Rakshit, Souvik, Dröge, Thomas, Glorius, Frank
Format: Artikel
Sprache:eng
Schlagworte:
Aniline Compounds - chemistry
Catalysis
Cyclization
CH activation
heterocycles
homogeneous catalysis
Indoles - chemical synthesis
Indoles - chemistry
indolines
palladium
Palladium - chemistry
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Zusammenfassung:Unreactive CH to attractive CN: A palladium‐catalyzed intramolecular direct amidation of unactivated C(sp3)H bonds combines CH activation and CN bond formation into one efficient process. Under the optimized conditions, an extraordinary tolerance of functional groups was observed, and numerous indoline derivatives were formed (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200903035