Cover Picture: Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2 (Angew. Chem. Int. Ed. 27/2007)

Cover Picture: Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2 (Angew. Chem. Int. Ed. 27/2007)

Hippocrates (the father of medicine) described the healing properties of St. John's wort 2500 years ago and prescribed it for the treatment of depression. Hyperforin, which is considered to be responsible for this activity, also has anticancer, antibacterial, and wound‐healing activity. A. Gian...

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Veröffentlicht in:Angewandte Chemie International Edition 2007-07, Vol.46 (27), p.5033-5033
Hauptverfasser: Gey, Claudia, Kyrylenko, Sergiy, Hennig, Lothar, Nguyen, Lien-Hoa D., Büttner, Anita, Pham, Hung D., Giannis, Athanassios
Format: Artikel
Sprache:eng
Schlagworte:
enzymes
epigenetics
inhibitors
natural products
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Zusammenfassung:Hippocrates (the father of medicine) described the healing properties of St. John's wort 2500 years ago and prescribed it for the treatment of depression. Hyperforin, which is considered to be responsible for this activity, also has anticancer, antibacterial, and wound‐healing activity. A. Giannis et al. describe in their Communication on page 5219 ff. that hyperforin and two related compounds are inhibitors of sirtuins SIRT1 and SIRT2. This property could explain some of the pharmacological properties of hyperforin.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200790122