Cover Picture: Oxetanes as Promising Modules in Drug Discovery (Angew. Chem. Int. Ed. 46/2006)

The oxetane ring is an orphan heterocycle in medicinal chemistry. In their Communication on page 7736 ff., M. Rogers‐Evans, E. M. Carreira, and co‐workers show that this structural motif can improve key physico‐ and pharmacochemical properties of an underlying scaffold. An “oxetane scan” within a series of lipophilic tertiary amine derivatives was performed to probe the influence of the oxetane ring on selected compound properties.