Ruthenium-Catalyzed Oxidative Cyanation of Tertiary Amines with Hydrogen Peroxide and Sodium Cyanide

Ruthenium-Catalyzed Oxidative Cyanation of Tertiary Amines with Hydrogen Peroxide and Sodium Cyanide

Versatile intermediates for the synthesis of N‐aryl‐α‐amino acids and N,N‐disubstituted 1,2‐diamines can now be synthesized with high efficiency by the ruthenium‐catalyzed oxidative cyanation of tertiary amines. The use of hydrogen peroxide as an oxidant in the presence of NaCN/AcOH or HCN provides...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2005-10, Vol.44 (42), p.6931-6933
Hauptverfasser: Murahashi, Shun-Ichi, Komiya, Naruyoshi, Terai, Hiroyuki
Format: Artikel
Sprache:eng
Schlagworte:
amines
Amines - chemical synthesis
Amines - chemistry
Catalysis
cyanides
hydrogen peroxide
Hydrogen Peroxide - chemistry
Molecular Structure
oxidation
Oxidation-Reduction
ruthenium
Ruthenium - chemistry
Sodium Cyanide - chemistry
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Versatile intermediates for the synthesis of N‐aryl‐α‐amino acids and N,N‐disubstituted 1,2‐diamines can now be synthesized with high efficiency by the ruthenium‐catalyzed oxidative cyanation of tertiary amines. The use of hydrogen peroxide as an oxidant in the presence of NaCN/AcOH or HCN provides the corresponding α‐aminonitriles (see reaction).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200501496