Cobalt(II)-Catalyzed Cross-Coupling of Polyfunctional Aryl Copper Reagents with Aryl Bromides and Chlorides

Cobalt(II)-Catalyzed Cross-Coupling of Polyfunctional Aryl Copper Reagents with Aryl Bromides and Chlorides

Polyfunctionalized biphenyl and heteroaromatic compounds were formed in the presence of [Co(acac)2], Bu4NI, and 4‐fluorostyrene (3) through a smooth cross‐coupling reaction between organocopper reagents 1, prepared by the transmetalation of functionalized aryl magnesium halides with CuCN⋅2 LiCl, and...

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Veröffentlicht in:Angewandte Chemie International Edition 2005-05, Vol.44 (19), p.2947-2951
Hauptverfasser: Korn, Tobias J., Knochel, Paul
Format: Artikel
Sprache:eng
Schlagworte:
Benzoates - chemistry
Bromine - chemistry
Catalysis
Chlorine - chemistry
cobalt
Cobalt - chemistry
Copper - chemistry
cross-coupling
Grignard reagents
heterocycles
Molecular Structure
Organic Chemicals - chemistry
organocopper compounds
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Beschreibung
Zusammenfassung:Polyfunctionalized biphenyl and heteroaromatic compounds were formed in the presence of [Co(acac)2], Bu4NI, and 4‐fluorostyrene (3) through a smooth cross‐coupling reaction between organocopper reagents 1, prepared by the transmetalation of functionalized aryl magnesium halides with CuCN⋅2 LiCl, and aryl halides 2 that bear electron‐withdrawing substituents. acac=acetylacetonate, DME=1,2‐dimethoxyethane, DMPU=1,3‐dimethyl‐3,4,5,6‐tetrahydro‐2(1H)‐pyrimidinone.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200500099