Structural Revision and Total Synthesis of Azaspiracid-1, Part 2: Definition of the ABCD Domain and Total Synthesis

The chase for the structure of azaspiracid‐1 has ended with a revised structure (see picture). The total synthesis of this challenging target has closed another chapter in this intriguing chemical detective story and allowed the assignment of the relative and absolute configuration of the molecule....

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Veröffentlicht in:	Angewandte Chemie International Edition 2004-08, Vol.43 (33), p.4318-4324
Hauptverfasser:	Nicolaou, K. C., Koftis, Theocharis V., Vyskocil, Stepan, Petrovic, Goran, Ling, Taotao, Yamada, Yoichi M. A., Tang, Wenjun, Frederick, Michael O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bivalvia - chemistry degradation studies Indicators and Reagents Magnetic Resonance Spectroscopy Marine Toxins - chemical synthesis Marine Toxins - chemistry Models, Molecular Molecular Structure natural products neurotoxins Spiro Compounds - chemical synthesis Spiro Compounds - chemistry structure elucidation total synthesis
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Beschreibung
Zusammenfassung:	The chase for the structure of azaspiracid‐1 has ended with a revised structure (see picture). The total synthesis of this challenging target has closed another chapter in this intriguing chemical detective story and allowed the assignment of the relative and absolute configuration of the molecule.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200460696