An Efficient Total Synthesis of Optically Active Tetrodotoxin

An Efficient Total Synthesis of Optically Active Tetrodotoxin

The toxic principle of puffer‐fish poison, (−)‐tetrodotoxin (1), has been recognized as a formidable synthetic target since its structure elucidation in 1964. An efficient total synthesis of 1 via the intermediate 2, which was used previously for the synthesis of 11‐deoxytetrodotoxin, is described....

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Veröffentlicht in:Angewandte Chemie International Edition 2004-09, Vol.43 (36), p.4782-4785
Hauptverfasser: Nishikawa, Toshio, Urabe, Daisuke, Isobe, Minoru
Format: Artikel
Sprache:eng
Schlagworte:
guanidine
ion channels
Molecular Conformation
natural products
tetrodotoxin
Tetrodotoxin - chemical synthesis
total synthesis
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Beschreibung
Zusammenfassung:The toxic principle of puffer‐fish poison, (−)‐tetrodotoxin (1), has been recognized as a formidable synthetic target since its structure elucidation in 1964. An efficient total synthesis of 1 via the intermediate 2, which was used previously for the synthesis of 11‐deoxytetrodotoxin, is described.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200460293