Efficient Asymmetric Hydrogenation of Pyridines

Efficient Asymmetric Hydrogenation of Pyridines

Up to four stereocenters can be created efficiently in a single step by the asymmetric hydrogenation of oxazolidinone‐substituted pyridines (see scheme). Furthermore, selective chirality transfer and nondestructive cleavage of the chiral auxiliary occur under the same reaction conditions, making an...

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Veröffentlicht in:Angewandte Chemie International Edition 2004-05, Vol.43 (21), p.2850-2852
Hauptverfasser: Glorius, Frank, Spielkamp, Nick, Holle, Sigrid, Goddard, Richard, Lehmann, Christian W.
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Sprache:eng
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asymmetric synthesis
chiral auxiliaries
heterogeneous catalysis
hydrogenation
piperidines
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container_end_page 2852
container_issue 21
container_start_page 2850
container_title Angewandte Chemie International Edition
container_volume 43
creator Glorius, Frank
Spielkamp, Nick
Holle, Sigrid
Goddard, Richard
Lehmann, Christian W.
description Up to four stereocenters can be created efficiently in a single step by the asymmetric hydrogenation of oxazolidinone‐substituted pyridines (see scheme). Furthermore, selective chirality transfer and nondestructive cleavage of the chiral auxiliary occur under the same reaction conditions, making an additional cleavage step unnecessary.
doi_str_mv 10.1002/anie.200453942
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source Wiley-Blackwell Journals
subjects asymmetric synthesis
chiral auxiliaries
heterogeneous catalysis
hydrogenation
piperidines
title Efficient Asymmetric Hydrogenation of Pyridines
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