Efficient Asymmetric Hydrogenation of Pyridines

Efficient Asymmetric Hydrogenation of Pyridines

Up to four stereocenters can be created efficiently in a single step by the asymmetric hydrogenation of oxazolidinone‐substituted pyridines (see scheme). Furthermore, selective chirality transfer and nondestructive cleavage of the chiral auxiliary occur under the same reaction conditions, making an...

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Veröffentlicht in:Angewandte Chemie International Edition 2004-05, Vol.43 (21), p.2850-2852
Hauptverfasser: Glorius, Frank, Spielkamp, Nick, Holle, Sigrid, Goddard, Richard, Lehmann, Christian W.
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric synthesis
chiral auxiliaries
heterogeneous catalysis
hydrogenation
piperidines
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Zusammenfassung:Up to four stereocenters can be created efficiently in a single step by the asymmetric hydrogenation of oxazolidinone‐substituted pyridines (see scheme). Furthermore, selective chirality transfer and nondestructive cleavage of the chiral auxiliary occur under the same reaction conditions, making an additional cleavage step unnecessary.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200453942