Protease-Catalyzed Peptide Synthesis from N- to C-Terminus: An Advantageous Strategy

Protease-Catalyzed Peptide Synthesis from N- to C-Terminus: An Advantageous Strategy

Not possible with chemical methods: Protein synthesis from the N‐ to C‐ terminus using the reverse hydrolysis potential of proteases was accompolished for the model petide 1. The stereo‐ and regiospecificity of the enzymes used ensured integrity of the stereogenic center and allowed ecological react...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 1997-05, Vol.36 (10), p.1099-1101
Hauptverfasser: Bordusa, Frank, Ullmann, Dirk, Jakubke, Hans-Dieter
Format: Artikel
Sprache:eng
Schlagworte:
bioorganic chemistry
chymotrypsin
clostripain
enzyme catalysis
peptides
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Not possible with chemical methods: Protein synthesis from the N‐ to C‐ terminus using the reverse hydrolysis potential of proteases was accompolished for the model petide 1. The stereo‐ and regiospecificity of the enzymes used ensured integrity of the stereogenic center and allowed ecological reaction conditions without side‐chain protection.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199710991