Total Synthesis of (−)-Epothilone A

Total Synthesis of (−)-Epothilone A

High diastereoselectivity is observed for the aldol reaction of the optically active building blocks 1 and 2. Another key step in the total synthesis of epothilone A is a ring‐closing metathesis. This highly convergent strategy offers many alternatives for the synthesis of biologically active analog...

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Veröffentlicht in:Angewandte Chemie International Edition 1997-03, Vol.36 (5), p.523-524
Hauptverfasser: Schinzer, Dieter, Limberg, Anja, Bauer, Armin, Böhm, Oliver M., Cordes, Martin
Format: Artikel
Sprache:eng
Schlagworte:
aldol reactions
epothilones
metathesis
natural products
total synthesis
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Beschreibung
Zusammenfassung:High diastereoselectivity is observed for the aldol reaction of the optically active building blocks 1 and 2. Another key step in the total synthesis of epothilone A is a ring‐closing metathesis. This highly convergent strategy offers many alternatives for the synthesis of biologically active analogs.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199705231