Immunization of Mice with a Fully Synthetic Globo H Antigen Results in Antibodies against Human Cancer Cells: A Combined Chemical-Immunological Approach to the Fashioning of an Anticancer Vaccine

Of mice and men: A vaccine composed of the fully synthetic globo H human breast tumor antigen 1 and a carrier protein elicits the formation of IgM antibodies in mice. These antibodies bind to MCF‐7 breast cancer cells and trigger effective complement‐mediated cell lysis. These promising results from the immune system of the mouse prompts a strategy to foster active immunity in humans.