Pr[MOE-DO3A], a Praseodymium Complex of a Tetraazacyclododecane: An In Vivo NMR Thermometer

Pr[MOE-DO3A], a Praseodymium Complex of a Tetraazacyclododecane: An In Vivo NMR Thermometer

The body temperature inside a living organism can be determined by measuring the 1HNMR chemical shifts of the paramagnetic praseodymium chelate complex 1. The complex is very stable and well‐tolerated. In a first in vivo application the temperature inside the liver of a living rat was determined wit...

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Veröffentlicht in:Angewandte Chemie International Edition 1996-04, Vol.35 (6), p.655-657
Hauptverfasser: Roth, K., Bartholomae, G., Bauer, H., Frenzel, T., Kossler, S., Platzek, J., Weinmann, H.-J.
Format: Artikel
Sprache:eng
Schlagworte:
chelate ligands
Dr. B. Radüchel
in vivo NMR spectroscopy
lan-thanide compounds
NMR spectroscopy
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Zusammenfassung:The body temperature inside a living organism can be determined by measuring the 1HNMR chemical shifts of the paramagnetic praseodymium chelate complex 1. The complex is very stable and well‐tolerated. In a first in vivo application the temperature inside the liver of a living rat was determined with an accuracy better than 0.5 K.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199606551