The First Recombinant Hydroxynitrile Lyase and its Application in the Synthesis of (S)-Cyanohydrins

The First Recombinant Hydroxynitrile Lyase and its Application in the Synthesis of (S)-Cyanohydrins

The cassava species Manihot esculenta provided the first recombinant hydroxynitrile lyase (MeHNL) that became accessible by overexpression in E. coli. This MeHNL catalyzes the enantioselective addition of HCN (depicted below) not only to aliphatic, aromatic, and heteroaromatic aldehydes, but also to...

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Veröffentlicht in:Angewandte Chemie International Edition 1996-03, Vol.35 (4), p.437-439
Hauptverfasser: Förster, Siegfried, Roos, Jürgen, Effenberger, Franz, Wajant, Harald, Sprauer, Achim
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Sprache:eng
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(S)-cyanohydrins
asymmetric syntheses
enzymatic catalysis
lyases
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container_title Angewandte Chemie International Edition
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creator Förster, Siegfried
Roos, Jürgen
Effenberger, Franz
Wajant, Harald
Sprauer, Achim
description The cassava species Manihot esculenta provided the first recombinant hydroxynitrile lyase (MeHNL) that became accessible by overexpression in E. coli. This MeHNL catalyzes the enantioselective addition of HCN (depicted below) not only to aliphatic, aromatic, and heteroaromatic aldehydes, but also to ketones to give (S)‐cyanohydrins in high optical yields. R  alkyl, aryl, heteroaryl; R1  H, CH3.
doi_str_mv 10.1002/anie.199604371
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subjects (S)-cyanohydrins
asymmetric syntheses
enzymatic catalysis
lyases
title The First Recombinant Hydroxynitrile Lyase and its Application in the Synthesis of (S)-Cyanohydrins
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