The First Recombinant Hydroxynitrile Lyase and its Application in the Synthesis of (S)-Cyanohydrins

The cassava species Manihot esculenta provided the first recombinant hydroxynitrile lyase (MeHNL) that became accessible by overexpression in E. coli. This MeHNL catalyzes the enantioselective addition of HCN (depicted below) not only to aliphatic, aromatic, and heteroaromatic aldehydes, but also to...

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Veröffentlicht in:Angewandte Chemie International Edition 1996-03, Vol.35 (4), p.437-439
Hauptverfasser: Förster, Siegfried, Roos, Jürgen, Effenberger, Franz, Wajant, Harald, Sprauer, Achim
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Sprache:eng
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Zusammenfassung:The cassava species Manihot esculenta provided the first recombinant hydroxynitrile lyase (MeHNL) that became accessible by overexpression in E. coli. This MeHNL catalyzes the enantioselective addition of HCN (depicted below) not only to aliphatic, aromatic, and heteroaromatic aldehydes, but also to ketones to give (S)‐cyanohydrins in high optical yields. R  alkyl, aryl, heteroaryl; R1  H, CH3.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199604371