Chiral Phosphanyldihydrooxazoles in Asymmetric Catalysis: Enantioselective Heck Reactions

Chiral Phosphanyldihydrooxazoles in Asymmetric Catalysis: Enantioselective Heck Reactions

Enantiomeric excesses of up to 99% have been obtained in Heck reactions of cyclic olefins with (phosphanyldihydrooxazole)Pd catalysts [Eq. (a)]. In contrast to analogous (BINAP)Pd‐catalyzed reactions, essentially no isomerization of the products by CC bond migration is observed.

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Veröffentlicht in:Angewandte Chemie International Edition 1996-02, Vol.35 (2), p.200-202
Hauptverfasser: Loiseleur, Olivier, Meier, Peter, Pfaltz, Andreas
Format: Artikel
Sprache:eng
Schlagworte:
asymmetric catalysis
dihydrooxazoles
Heck reactions
N ligands
P,N ligands
palladium catalysts
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Zusammenfassung:Enantiomeric excesses of up to 99% have been obtained in Heck reactions of cyclic olefins with (phosphanyldihydrooxazole)Pd catalysts [Eq. (a)]. In contrast to analogous (BINAP)Pd‐catalyzed reactions, essentially no isomerization of the products by CC bond migration is observed.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199602001